| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6263911 | Brain Research | 2013 | 9 Pages |
Flavonoids have known anti-inflammatory and antioxidative actions, and they have been described as neuroprotective and able to reduce damage in CNS diseases. We evaluated the action of the flavonoid rutin in an animal model of focal cortical ischemia induced by unilateral thermocoagulation of superficial blood vessels of motor (M1) and somatosensory (S1) primary cortices. Ischemic rats were submitted to daily injections (i.p.) for five days, starting immediately after induction of ischemia. We tested two doses: 50Â mg/kg or 100Â mg/kg of body weight. Sensorimotor tests were used to evaluate functional recovery. Bioavailability in plasma was done by chromatographic analysis. The effect of treatment in lesion volume and neurodegeneration was evaluated 48Â h and 72Â h after ischemia, respectively. We observed significant sensorimotor recovery induced by rutin, and the dose of 50Â mg/kg had more pronounced effect. Thus, this dose was used in further analyses. Plasma availability of rutin was detected from 2Â h to at least 8Â h after ischemia. The treatment did not result in reduction of lesion volume but reduced the number of degenerated neurons at the periphery of the lesion. The results suggest rutin as an efficient drug to treat brain ischemia since it was able to promote significant recovery of sensorimotor loss, which was correlated to the reduction of neurodegeneration in the periphery of cortical injury. Increasing studies with rutin and other flavonoids might give support for further clinical trials with these drugs.
⺠We evaluated the action of flavonoid rutin in a model of focal cortical ischemia. ⺠Rutin was administrated after induction of ischemia. ⺠Rutin promoted sensorimotor recovery and decreased neurodegeneration. ⺠Rutin might be used to treat acute phase of stroke.
