| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6264157 | Brain Research | 2012 | 16 Pages |
Abstract
⺠Dopamine induces endosomal translocation of APP in Neuro2A neuroblastoma cells. ⺠Dopamine promotes amyloidogenic processing of APP within endosomes. ⺠Amyloidogenic processing of APP eventually causes lysosome leakage and apoptosis. ⺠Pepstatin A and chloroquine inhibit dopamine-induced processing of APP. ⺠Pepstatin A and chloroquine prevent apoptosis induced by dopamine.
Keywords
FITCGFPPhorbol 12-myristate-13-acetatePepstatin AzVAD-fmkterminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labelingDAPI4′,6-diamidino-2-phenylindole dihydrochloridePMAbenzyloxycarbonyl-Val-Ala-Asp-fluoromethylketoneAlzheimer's diseaseParkinson's diseaseTUNELDopaminefluorescein isothiocyanateLysosomegreen fluorescent proteinPropidium iodideChloroquine
Related Topics
Life Sciences
Neuroscience
Neuroscience (General)
Authors
Monica Cagnin, Matteo Ozzano, Natascia Bellio, Ilaria Fiorentino, Carlo Follo, Ciro Isidoro,