| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6264329 | Brain Research | 2012 | 9 Pages |
The objective of this study was to observe the pathophysiological time window of performing minimally invasive procedures for the intracerebral hematoma evacuation. Thirty-six rabbits were randomly placed in either a normal control group (NC group, 6 rabbits), a model control group (MC group, 6 rabbits) or a minimally invasive group (MI group, 24 rabbits). A model of intracerebral hemorrhage (ICH) was established in the MC and MI groups. In the MI group, the intracerebral hematoma was evacuated by stereotactic minimally invasive procedures over 6Â h (6 rabbits), 12Â h (6 rabbits), 18Â h (6 rabbits) and 24Â h (6 rabbits), following successful induction of ICH. All of the animals in each group were sacrificed 48Â h after the successful induction of ICH. Perihematomal brain tissues were removed to determine the glutamate level, BBB permeability and brain water content (BWC). The perihematomal glutamate level, BBB permeability and the BWC in the MI group were significantly decreased compared with those of the MC group. Performing minimally invasive procedures for evacuation of ICH in 6Â h showed the most remarkable decrease of the glutamate level, BBB permeability and BWC, followed by a significant difference observed at 12Â h within the MI subgroups. Performing minimally invasive procedures in early stages after ICH for the hematoma evacuation could decrease the perihematomal glutamate level, BBB permeability and BWC significantly. The pathophysiological time window of minimally invasive procedures for hematoma evacuation might be 6-12Â h after hemorrhage.
⺠This study aimed to provide the pathophysiological evidences for the time window of a minimally invasive surgery for ICH. ⺠The perihematomal glutamate, BBB permeability and the BWC increased significantly after the after the ICH was induced. ⺠The perihematomal glutamate level, BBB permeability and BWC decreased remarkably after the minimally invasive surgery. ⺠The neurological functions were improved after the minimally invasive surgery compared with the model control group. ⺠The optimal pathophysiological time window of performing the minimally invasive surgery for ICH was 6-12 hours after onset.
