Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6264543 | Brain Research | 2012 | 11 Pages |
Abstract
⺠In vitro estradiol directly attenuated sodium currents in GnRH neurons from young and aged animals. ⺠Estradiol modulation of sodium current was time-dependent, and mediated through ERβ. ⺠Estradiol directly attenuated the DAP; modulation was not time-dependent or mediated through ERβ. ⺠The DAP was not modulated in neurons from aged animals. ⺠These results suggest that estradiol regulation of GnRH neuronal output is modulated during aging.
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Authors
Yong Wang, M. Cathleen Kuehl-Kovarik,