Article ID Journal Published Year Pages File Type
6265053 Brain Research 2011 10 Pages PDF
Abstract

Oxidative stress plays an important role in Parkinson's disease and other neurodegenerative disorders. Salidroside, a phenylpropanoid glycoside isolated from Rhodiola rosea L., has potent antioxidant properties. In the present study, we investigated the protective activity of salidroside against 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in PC12 cells. We found that incubation of PC12 cells with salidroside prior to MPP+ exposure significantly reduced cell apoptosis and attenuated collapse of the mitochondrial membrane potential (MMP). Furthermore, salidroside inhibited the MPP+-induced nitric oxide (NO) increase and overexpression of nNOS and iNOS and suppressed accumulation of reactive oxygen species (ROS) and intracellular free Ca2+. Our results show that the protective effects of salidroside on PC12 cells are mediated, at least in part, by inhibition of the NO pathway.

Research Highlights► NO plays an important role in the pathogenesis of PD. ► NO can mediate neurotoxicity and cause neuronal cell death. ► Salidroside have strong antioxidant and neuroprotectant. ► Salidroside are protective for the pc12 cells against MPP+ intoxication. ► Salidroside can possibly be used as a neuroprotective agent for treatment of PD.

Related Topics
Life Sciences Neuroscience Neuroscience (General)
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