| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6265312 | Brain Research | 2011 | 11 Pages |
Abstract
âºNeurotrophic factors are necessary for endogenous neurogenesis after brain ischemia. âºhBMSCs treatment increases the expression of BDNF, NT-3, and VEGF in ischemic brain. âºhBMSCs enhance proliferation of neuronal progenitor cells in the SVZ and SGZ. âºhBMSCs accelerate migration of newborn neuroblasts to the ischemic boundary zone. âºhBMSCs promote newborn neuroblasts differentiation to neurons and reduce apoptosis.
Keywords
hBMSCsNT-3SVZSGZischemic boundary zoneDcxMCAOIBZBDNFmiddle cerebral artery occlusionCerebral ischemiaBrdUbromodeoxyuridinedoublecortinMesenchymal stem cellHuman bone marrow-derived mesenchymal stem cellsVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)Brain-derived neurotrophic factorbone marrowsubgranular zonesubventricular zoneneurotrophin-3NeurogenesisTransplantation
Related Topics
Life Sciences
Neuroscience
Neuroscience (General)
Authors
Xinjie Bao, Junji Wei, Ming Feng, Shan Lu, Guilin Li, Wanchen Dou, Wenbin Ma, Sihai Ma, Yihua An, Chuan Qin, Robert Chunhua Zhao, Renzhi Wang,