| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6265904 | Brain Research | 2007 | 6 Pages |
Abstract
PACAP in the retinohypothalamic tract mediates photic information to the suprachiasmatic nucleus via the PAC1 receptor. The diurnal and circadian VIP mRNA expressions in the suprachiasmatic nucleus of PAC1â/â and wild type mice were quantified. During light/dark cycles identical VIP mRNA rhythms were found while the oscillation pattern differed between the two types of animals during constant darkness. The results show that the circadian VIP mRNA expression is influenced by the absence of PAC1 signalling.
Keywords
RT-PCRVPAC2PAC1VPAC1ipRGCSCNRHTPACAPVIPconstant darknesslight/darkCircadian Timecircadianretinohypothalamic tractZeitgeber timeReal-time RT-PCRwild typeSuprachiasmatic nucleusreverse transcriptase polymerase chain reactionpituitary adenylate cyclase activating polypeptideVasoactive intestinal polypeptide
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Authors
Birgitte Georg, Jens Hannibal, Jan Fahrenkrug,