Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6266355 | Current Opinion in Neurobiology | 2015 | 5 Pages |
â¢Experience-dependent maturation of inhibition strengthens ipsilateral eye inputs.â¢Once established, inhibition is detrimental to competitive plasticity.â¢Disinhibition promotes synaptic depression and ocular dominance plasticity.â¢Feed-forward input to fast-spiking interneurons gates critical period plasticity.
Maturation of cortical inhibition just after eye opening is a necessary precedent for the emergence of competitive, experience-dependent ocular dominance plasticity in the visual cortex. What inhibition is doing in this context, though, is not clear. Here I outline new hypotheses on the roles of somatic and dendritic inhibition in the opening and closure of critical periods, and their roles in the competitive processes therein.