| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6266982 | Current Opinion in Neurobiology | 2012 | 7 Pages |
Abstract
Toward the functional dissection of neuronal circuits, a number of new genetic tools have been developed that enable rapid and reversible manipulation of genetically defined neuronal subtypes in intact mammalian brain circuits. Alongside the breakthrough technology of optogenetics, receptor-ligand pairs provide complementary approaches to modulate neuronal activity using chemical genetics.
⺠Rapid modulation of neuronal activity allows functional dissection of circuits. ⺠Optogenetics and chemical genetics provide alternative and complementary approaches. ⺠We review progress in the use of receptor-ligand pairs as chemical-genetic tools.
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Authors
Peer Wulff, Benjamin R Arenkiel,