| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6267322 | Current Opinion in Neurobiology | 2012 | 7 Pages |
Abstract
⺠ARX is a transcription factor deeply involved in interneuron development. ⺠ARX mutations can cause epilepsy, infantile spasms, and intellectual disability. ⺠Downstream consequences of Arx mutations reveal complex molecular pathogenesis. ⺠Mouse models of human ARX mutations are valuable tools to study role of Arx in vivo. ⺠New mouse models provide a substrate for the investigation of novel therapies.
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Authors
Pedro R Olivetti, Jeffrey L Noebels,