| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6268697 | Journal of Neuroscience Methods | 2014 | 8 Pages |
Abstract
We present a BBB model for leukocyte transmigration incorporating shear stress with co-culture of hBMVEC and hAST. We demonstrate that hAST promoted leukocyte transmigration and also increased certain barrier functions of hBMVEC. This model provides reproducible assays for leukocyte transmigration with robust results, which will enable further defining the relationships among leukocytes and the cellular elements of the BBB.
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Neuroscience
Neuroscience (General)
Authors
Yukio Takeshita, Birgit Obermeier, Anne Cotleur, Yasuteru Sano, Takashi Kanda, Richard M. Ransohoff,