Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6269443 | Journal of Neuroscience Methods | 2013 | 6 Pages |
A prototype for a non-invasive, real-time, monitoring device was developed to detect changes in the brain secondary to disease or injury such as intracerebral hemorrhage (ICH). The eventual goal is a non-invasive, real time sensor that can alert the clinician to alterations in the comatose patient's brain resulting from hemorrhage, seizure or stroke. In this work, a 400Â MHz electromagnetic (EM) signal was transmitted with an antenna (T), incident on a 'brain gel' in vitro ICH model, and received by a receiving (R) antenna. Changes in the received signal were found to be induced by the presence of blood. The received power (PR) was found to be a linear function of the cross sectional area of blood, as measured normal to the incident wave. In addition, the sensor was able to detect as little as 1Â mL of blood in this 1000Â mL in vitro model.
⺠We demonstrate a prototype device to monitor intracerebral hemorrhage. ⺠This device is tested in an in vitro brain gel model. ⺠It can detect as little as 1 mL of blood in this model. ⺠This technique could be developed as a non-invasive sensor of brain status.