| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6269767 | Journal of Neuroscience Methods | 2011 | 4 Pages |
Dimethyl sulfoxide (DMSO) is a widely used solvent for water-insoluble molecules and it has antioxidant, neuroprotective and cryopreservative effects. While DMSO is a regularly used solvent in research and a therapeutic agent, several cases of DMSO evoked seizures were reported in the literature. Therefore, we investigated the effect of different doses of DMSO on the absence-like epileptic activity of Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. We revealed that low doses of DMSO decreased whereas high doses of DMSO increased the absence-like epileptic activity of WAG/Rij rats.
Research highlights⺠Different doses of DMSO differently changed the SWD activity of the WAG/Rij rats. ⺠Low doses of DMSO decreased the SWD number between 30 and 90 min after i.p. injection. ⺠Intermediate DMSO doses had no significant effect on SWD number. ⺠High doses of DMSO increased the SWD number for up to 210 min.
