A multi-slice recording system for stable late phase hippocampal long-term potentiation experiments

▶ This multi-slice recording system not only improves throughput and therefore the number of used brain slices per animal, but also allows better statistical design and enables very robust LTP measurements for up to 7 h. ▶ This system is suitable not only to investigate molecular mechanisms underlying the late phase of LTP, but also to screen candidate compounds in the context of drug discovery. ▶ We expect that the upgraded multi-slice recording system presented is of broad interest especially to researchers in the field of leaning and memory.