A randomized, placebo-controlled trial of the benzoquinone idebenone in a mouse model of OPA1-related dominant optic atrophy reveals a limited therapeutic effect on retinal ganglion cell dendropathy and visual function

Article ID	Journal	Published Year	Pages	File Type
6271363	Neuroscience	2016	43 Pages	PDF

Abstract

Idebenone appears largely ineffective in protecting Opa1 heterozygous RGCs from dendropathy. The detrimental effect of idebenone in wildtype mice has not been previously observed and raises some concerns.

Keywords

Glc INL 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate DiI inner nuclear layer ganglion cell layer