Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6271400 | Neuroscience | 2016 | 19 Pages |
Abstract
We observed that intragastric administration of FA increased the brain levels of TRP and the central and peripheral concentrations of kynurenic acid (KYNA), as well as caused significant changes in the brain and plasma concentrations of BCAA and AAA. We found that the administration of FA clearly increased the seizure threshold and induced sedation. Furthermore, we have demonstrated that blocking TRP passage into the brain abolished these effects of FA but had no similar effect on the formation of ketone bodies. Given that FAs are major components of a ketogenic diet, it is suggested that the anticonvulsant effects of a ketogenic diet may be at least partly dependent on changes in TRP metabolism. We also propose a more general hypothesis concerning the intracellular mechanism of the ketogenic diet.
Keywords
MCTBHMC10LNAAAAAAAT5-HIAADOPACADTLEUl-isoleucineL-lysineALA5-HTLACASPFAS3,4-dihydroxyphenylacetic acid5-hydroxyindole acetic acidl-leucineaspartateAspartate aminotransferasealaninebranched-chain amino acidsDecanoic acidLarge neutral amino acidaromatic amino acidsOctanoic acidβ-hydroxybutyric acidkynurenic acidFatty acidsBCAAMASMedium-chain triglycerideKYNDopamineBlood–brain barrierBBBSerotoninmalate-aspartate shuttleLactatelactate dehydrogenaseLDHLYShomovanillic acidHVAKYNAkynurenineGluglutamateglutamineGlyGlycine
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Authors
P. Maciejak, J. Szyndler, D. TurzyÅska, A. Sobolewska, K. KoÅosowska, P. KrzÄ
Åcik, A. PÅaźnik,