A novel dualistic profile of an allosteric AMPA receptor modulator identified through studies on recombinant receptors, mouse hippocampal synapses and crystal structures

Article ID	Journal	Published Year	Pages	File Type
6271522	Neuroscience	2015	14 Pages	PDF

Keywords

fEPSP PPF DEPC CA1 LBD RMSD aCSF PAM CTZ AMPA BDNF DMSO cornu ammonis area 1 MOLA paired-pulse facilitation long-term potentiation LTP outside-out patch ligand-binding domain diethylpyrocarbonate Molecular dynamics Dimethyl sulfoxide Crystal structure cyclothiazide Brain-derived neurotrophic factor artificial cerebrospinal fluid Allosteric modulator positive allosteric modulator root mean square deviation Hippocampus Field excitatory postsynaptic potential Synaptic plasticity AMPA receptor

Related Topics

Life Sciences Neuroscience Neuroscience (General)

Authors

G.B. Christiansen, B. Harbak, S.E. Hede, A.H. Gouliaev, L. Olsen, K. Frydenvang, J. Egebjerg, J.S. Kastrup, M.M. Holm,