| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6272826 | Neuroscience | 2015 | 41 Pages |
Abstract
This study provided evidence of a key role for the GABA system in neurodevelopment associated with the etiopathogenesis of schizophrenia and showed that the observed changes are sex-dependent. Moreover, this study is the first to present a model of schizophrenia based on prenatal LPS administration, which not only produced behavioral abnormalities but also changed the cytoarchitecture of the GABA inhibitory system.
Keywords
prepulseTBSTMK-801PBSLPSIL-6IL-2IODSDSGad67IL-1βTBSGAPDHPPITris-buffered saline containing 0.1% Tween-20gamma-aminobutyric acidinterleukin 1βinterleukin 2interleukin 6analysis of varianceANOVAintegrated optical densityTris-buffered salineSocial interactiontumor necrosis factor αstandard error of the meandizocilpinesodium dodecyl sulfatedentate gyrusTNF-αlipopolysaccharidePhosphate-buffered salineSEMPrepulse inhibitionvehVehicleGABAGlutamate decarboxylaseglyceraldehyde 3-phosphate dehydrogenaseSensorimotor gatingEstrogen receptor
Related Topics
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Neuroscience
Neuroscience (General)
Authors
A. Basta-Kaim, K. FijaÅ, J. Ålusarczyk, E. Trojan, K. GÅombik, B. Budziszewska, M. LeÅkiewicz, M. Regulska, M. Kubera, W. LasoÅ, K. WÄdzony,