| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6273438 | Neuroscience | 2014 | 14 Pages |
Abstract
This review highlights some research studying changes in the epigenetic patterns intrinsic to genes of 5-HTT and BDNF, which are related to lifelong environmental adversities, which in turn increases the risks of developing MDD.
Keywords
ACTHMPFCTrkBCpGCREBMDDHDACBLAPFC5-HTbasolateral amygdalaBDNFMajor depressive disorderDepressionEpigeneticlong-term potentiationLTPTyrosine kinase BSERTSerotoninserotonin transporterBrain-derived neurotrophic factorprefrontal cortexmedial prefrontal cortexSelective serotonin reuptake inhibitorSSRIHPAadrenocorticotropic hormonehypothalamic–pituitary–adrenalcAMP response element-binding proteinPolymorphismSingle-nucleotide polymorphismSNPHATglucocorticoid receptor
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Authors
Z.M. Ignácio, G.Z. Réus, H.M. Abelaira, J. Quevedo,