Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6273656 | Neuroscience | 2014 | 9 Pages |
Abstract
In conclusion, these findings indicate that GPNMB has neuroprotective effects against IRI, via phosphorylation of ERK1/2 and Akt, suggesting that GPNMB may be a therapeutic target for ischemia-reperfusion injuries.
Keywords
TTCGPNMBMAP2MCAOGFAPPBS2,3,5-triphenyltetrazolium chlorideERK1/2IRIIschemia–reperfusion injuryEDTAEthylenediaminetetraacetic acidamyotrophic lateral sclerosismiddle cerebral artery occlusionImmunohistochemistryIHCphosphate bufferALSTransgenicStrokeNeuroprotectionPhosphate-buffered salinewild-typeGlial fibrillary acidic proteinmicrotubule-associated protein 2Protein kinase B (AKT)extracellular signal-regulated kinase 1 and 2
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Authors
Y. Nakano, Y. Suzuki, T. Takagi, A. Kitashoji, Y. Ono, K. Tsuruma, S. Yoshimura, M. Shimazawa, T. Iwama, H. Hara,