| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6273770 | Neuroscience | 2014 | 15 Pages |
Abstract
- Tetramethylpyrazine (TMP) promotes SH-SY5Y cell differentiation into neuronal phenotype cell.
- TMP induces neuronal differentiation of SH-SY5Y cell through up-regulating Topoisomerase IIβ (TopoIIβ).
- TMP increases the levels of global acetylated histone H3 and H4 which were positively correlated with TopoIIβ expression.
- Transcriptional activation of TopoIIβ gene is due to hyperacetylation of histone H3 and H4 at its proximal promoter region.
- TMP could be used as a promising candidate in drug-therapy of neuron injuries and neurodegenerative diseases in future.
Keywords
PBSacetylated histone H3topoisomerase IIβTopoisomerase IIMAP2Ac-H3TMPTSSDMEMHDACsDMSOMTTTetramethylpyrazineHistone acetylationchromatin immunoprecipitationNeuronal differentiationDimethylsulfoxideNeurite outgrowthtranscription start siteSH-SY5Y cellPhosphate-buffered salineDulbecco’s modified eagle’s mediumhistone deacetylaseshistone acetyltransferasespolymerase chain reactionPCRmicrotubule-associated protein 2CHiPHATs
Related Topics
Life Sciences
Neuroscience
Neuroscience (General)
Authors
Y. Yan, J. Zhao, C. Cao, Z. Jia, N. Zhou, S. Han, Y. Wang, Y. Xu, J. Zhao, Y. Yan, H. Cui,