Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6273906 | Neuroscience | 2014 | 13 Pages |
Abstract
This study provides the first demonstration that chronic inflammation of tooth pulp induces persistent bilateral activation of ERK and p38 within Vc, and that this activation is further increased by acute stimulation. This altered activity in intracellular signaling is likely to be linked to the sensitization that is seen in our animal model and in patients with pulpitis. Our data indicate that pERK and pp38 are more accurate markers of central change than Fos expression. In our model, localization of pERK and pp38 within specific cell types differs from that seen following acute stimulation. This may indicate specific roles for different cell types in the induction and maintenance of pulpitic and other types of pain.
Keywords
NeuNIndocarbocyanineCy3AOIp38NDSERKPBSTNGSGFAPCFAPBSFITCcomplete Freund’s adjuvantMAPKp38 MAPKEMGelectromyogramanalysis of varianceANOVAJORjaw-opening reflexnormal goat serumnormal donkey serumfluorescein isothiocyanatePhosphate-buffered salinearea of interestGlial fibrillary acidic proteinneuron-specific nuclear proteinmitogen-activated protein kinaseextracellular signal-regulated kinase
Related Topics
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Neuroscience
Neuroscience (General)
Authors
M.A. Worsley, C.E. Allen, A. Billinton, A.E. King, F.M. Boissonade,