| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6273964 | Neuroscience | 2014 | 10 Pages |
Abstract
Our results provide strong evidence that M1/4 receptor modulation after simvastatin administration did, at least partially, contribute to the improvement in the long-term memory in 6-OHDA-induced PD rats. These results provide a possible mechanism for simvastatin treatment in psycho-neurological diseases such as PD via M1/4 receptors.
Keywords
ABCvertical limb of the diagonal bandRSGVDBTHAPRHVMHPMCoMFBMWMVTASNRENTDMH6-HydroxydopamineHEPESCPUDAB6-OHDA2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonic acidAcbSNpcmedial amygdalaAmygdalaAMYmedial forebrain bundlePirAlzheimer’s diseaseParkinson’s diseaseThalamusanalysis of varianceANOVAOlfactory tubercletyrosine hydroxylaseMemorydiaminobenzidineSimvastatinEntorhinal cortexprimary motor cortexretrosplenial granular cortexAgranular insular cortexperirhinal cortexpiriform cortexArcLow-density lipoproteinLDLMorris water mazeHIPventral tegmental areaaccumbens nucleusdorsomedial hypothalamic nucleusarcuate hypothalamic nucleusVentromedial hypothalamusHippocampusCaudate putamencingulate cortex
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Authors
Q. Wang, X. Wei, H. Gao, J. Li, J. Liao, X. Liu, B. Qin, Y. Yu, C. Deng, B. Tang, X.-F. Huang,