Lack of BDNF expression through promoter IV disturbs expression of monoamine genes in the frontal cortex and hippocampus

Article ID	Journal	Published Year	Pages	File Type
6274084	Neuroscience	2014	11 Pages	PDF

Abstract

- Lack of activity-driven BDNF disturbs expression of monoamine genes.
- More changes in the frontal cortex than in hippocampus.
- Reduced serotonin receptors 1b, 2a, and 5b, but increased tryptophan hydroxylase.
- Reduced dopamine D2 receptor but increased dopamine D4 receptor.
- Reduced adrenaline receptors Î±1a and Î±1d.

Keywords

KIV ADR FDR DRD2 norepinephrine transporter DRD4 Tph IPSC qRT-PCR DAT BDNF EPSC cycle threshold EDTA Ethylenediaminetetraacetic acid Dopamine transporter Gene expression tyrosine hydroxylase inhibitory postsynaptic current excitatory postsynaptic current NET standard error of mean Brain-derived neurotrophic factor frontal cortex HIP Selective serotonin reuptake inhibitor SSRI false discovery rate wild-type tryptophan hydroxylase Hippocampus quantitative reverse-transcription polymerase chain reaction Dopamine D4 receptor adrenergic receptor dopamine D2 receptor