Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6274257 | Neuroscience | 2013 | 19 Pages |
Abstract
Methylxanthines (e.g. caffeine, theophylline) do not perturb bursting of rhythmogenic pre-Bötzinger complex (preBötC) inspiratory networks in isolated newborn rat brainstem-spinal cords, but mask simultaneously recorded bursting of preBötC-driven motoneurons in hypoglossal (XII) nucleus via 1-10Â Hz oscillations. As measured in a different preparation, they evoke seizure-like discharges in preBötC-driven spinal motor networks as exemplified by recording from the fourth cervical (C4) motor nerve roots.
Keywords
HEPESDPCPXpFRGDMPXVRCPDE4RTNCPA3,7-dimethyl-1-propargylxanthine8-Cyclopentyl-1,3-dipropylxanthineApnea of prematurityCyclopiazonic acidhydroxyethyl piperazineethanesulfonic acidEpilepsySeizurespostnatal dayVentral respiratory columnphosphodiesterase-4ThoracicSERCApre-Bötzinger complexRhythm generationnetwork oscillationsRetrotrapezoid nucleuspreBötCparafacial respiratory group
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Authors
B. Panaitescu, J. Kuribayashi, A. Ruangkittisakul, V. Leung, M. Iizuka, K. Ballanyi,