Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6274379 | Neuroscience | 2013 | 19 Pages |
Abstract
In this review we discuss recent advances in the understanding of the development of forebrain projections attending to their origin, fate determination, and axon guidance. Major forebrain connections include callosal, corticospinal, corticothalamic and thalamocortical projections. Although distinct transcriptional programs specify these subpopulations of projecting neurons, the mechanisms involved in their axonal development are similar. Guidance by short- and long-range molecular cues, interaction with intermediate target populations and activity-dependent mechanisms contribute to their development. Moreover, some of these connections interact with each other showing that the development of these axonal tracts is a well-orchestrated event. Finally, we will recapitulate recent discoveries that challenge the field of neural wiring that show that these forebrain connections can be changed once formed. The field of reprogramming has arrived to postmitotic cortical neurons and has showed us that forebrain connectivity is not immutable and might be changed by manipulations in the transcriptional program of matured cells.
Keywords
MGNventral telencephalonSpecial AT-rich sequence-binding protein 2Deleted in colorectal carcinomaPSPBCorticospinal motor neuronsCTIP2SATB2DTBCPNNCAMPRNCorpus callosumventrobasal nucleusRTNSVZCTATCAdLGNIGF-1DCCCStDorsal funiculusthalamocortical axonsinsulin-like growth factor-1fate determinationcorticospinal tractAxon guidanceembryonic daycortical plateTranscription factorAuditory CortexVisual cortexventricular zonesubventricular zoneintermediate zoneneural cell adhesion moleculeneuropilin-1reticular thalamic nucleusdorsal lateral geniculate nucleusmedial geniculate nucleusinternal capsule
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Authors
E. Leyva-DÃaz, G. López-Bendito,