Neuroscience Forefront ReviewGeneralization of perceptual and motor learning: A causal link with memory encoding and consolidation?

•Evidence for perceptual and motor learning generalization is reviewed.•Generalization can be affected by the encoding and consolidation of the memory.•Generalization may be facilitated by engagement of higher-order brain areas.•Repeated task exposure may alter generalization and overall offline learning.•Generalization may be supported by sleep.

In both perceptual and motor learning, numerous studies have shown specificity of learning to the trained eye or hand and to the physical features of the task. However, generalization of learning is possible in both perceptual and motor domains. Here, I review evidence for perceptual and motor learning generalization, suggesting that generalization patterns are affected by the way in which the original memory is encoded and consolidated. Generalization may be facilitated during fast learning, with possible engagement of higher-order brain areas recurrently interacting with the primary visual or motor cortices encoding the stimuli or movements' memories. Such generalization may be supported by sleep, involving functional interactions between low and higher-order brain areas. Repeated exposure to the task may alter generalization patterns of learning and overall offline learning. Development of unifying frameworks across learning modalities and better understanding of the conditions under which learning can generalize may enable to gain insight regarding the neural mechanisms underlying procedural learning and have useful clinical implications.