| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6274449 | Neuroscience | 2013 | 6 Pages |
Abstract
Certain patterns of neural activity can induce N-methyl-d-aspartic acid receptor (NMDAR)-dependent synaptic plasticity, one of the important foundations of memory. Here, we report that a patterned high-frequency stimulation (PHS) induces rat hippocampal long-term depression (LTD) in an NMDAR-independent manner that requires coactivation of GABAARs and muscarinic acetylcholine receptors (mAChRs), and endocytosis of AMPARs. Thus, we disclose that a patterned high-frequency stimulation triggers GABAAR and mAChR-dependent LTD in the hippocampus.
Keywords
HFSATRPMCPGBICTBSSTIPHSLFSmAChRBicucullinemGluRaCSFN-methyl-d-aspartic acid receptorPTXNMDAR(RS)-α-Methyl-4-carboxyphenylglycineD-(−)-2-amino-5-phosphonopentanoic acidd-AP5DMSOfEPSPsAtropineAChAcetylcholineScopolaminelong-term depressionStimulationlow-frequency stimulationtheta burst stimulationhigh-frequency stimulationlong-term potentiationLTPDimethyl sulfoxideinter-burst intervalartificial cerebrospinal fluidLTDHippocampal CA1IBIfield excitatory postsynaptic potentialsPicrotoxinmuscarinic acetylcholine receptorGABAA receptorsMetabotropic glutamate receptor
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Authors
Y.-Y. Zhu, L. Jing, T.-T. Duan, Q. Yuan, J. Cao, Q.-X. Zhou, L. Xu,