Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6274697 | Neuroscience | 2013 | 17 Pages |
Abstract
Taken together, our data support the conclusion that GHB may be exerting its actions on state and motor control, in part, via an acutely mediated strong inhibition of serotonergic DR neurons and a more modest inhibitory action on a smaller proportion of LDT cholinergic neurons. Given the roles played by these nuclei, these actions are consistent with acute pharmacologic effects of GHB: hypotonia and promotion of sleep, including presence of REM, a sub-state of sleep. Differences in GHB-mediated calcium suggest differential regulation of calcium-dependent processes, which may also contribute to functioning of the LDT and DR in state and motor control and the therapeutic pharmacologic actions of GHB, which develop following chronic administration. These findings add to knowledge of cellular actions of GHB and it is hoped that, combined with findings from other studies examining GHB neurotransmission, these data can contribute to development of highly targeted therapeutics at the GABAB receptor for management of human disorders presenting with alterations in motor and arousal control.
Keywords
TphnNOSHEPESGHBK–SROIEGTATTXVTAaCSFLDT4-(2-hydroxyethyl)-1-piperazineethanesulfonic acidDMSOγ-hydroxybutyric acidAChethylene glycol tetraacetic acidAcetylcholineBaclofentetrodotoxinlaterodorsal tegmentumNarcolepsyREM sleepDimethyl sulfoxideDorsal raphé neuronal nitric oxide synthaseartificial cerebrospinal fluidRegions Of Interestventral tegmental areatryptophan hydroxylaseKolmogorov–SmirnovSuccinic semialdehyde dehydrogenase deficiencyGABA
Related Topics
Life Sciences
Neuroscience
Neuroscience (General)
Authors
K.A. Kohlmeier, B. Vardar, M.H. Christensen,