Phosphatidylinositol 3 kinase/protein kinase B is responsible for the protection of paeoniflorin upon H2O2-induced neural progenitor cell injury

Article ID	Journal	Published Year	Pages	File Type
6274900	Neuroscience	2013	9 Pages	PDF

Abstract

âº Paeoniflorin confers protective effects to NPCs against oxidative stress-induced apoptosis. âº PF inhibited H2O2-induced NPC apoptosis by increasing Procaspase-3 and balancing Bcl-2/Bax expression. âº Paeoniflorin-mediated protection of NPCs is reliant upon the PI3K/Akt-1 signaling pathway.

Keywords

HRP bFGF EGF paeoniflorin NSC SGZ PVDF HBSS 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide DMEM/F12 MTT NPCs ROS Hydrogen peroxide Antioxidant Bax analysis of variance ANOVA Terminal deoxynucleotidyl transferase dUTP nick end labeling TUNEL Apoptosis CNS polyvinylidene difluoride Neural stem cells Neural progenitor cells central nervous system epidermal growth factor basic fibroblast growth factor lactate dehydrogenase LDH Hank’s balanced salt solution subgranular zone H2O2 Horseradish peroxidase Bcl-2-associated X protein Reactive oxygen species