| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6274939 | Neuroscience | 2013 | 11 Pages |
Abstract
⺠Postnatal 5-HT depletion led to unbalanced long-term plasticity in juvenile rats. ⺠Citalopram suppressed LTP of excitatory and inhibitory inputs onto principal cells. ⺠LTP induction in 5-HT depleted slices disrupted the excitatory-inhibitory balance. ⺠5-HT1A receptor blockade with WAY100,635 mimicked the effects of 5-HT depletion.
Keywords
HEPESEGTART-PCRPCPAaCSFPBSsIPSCsE-LTPsEPSCs4-(2-hydroxyethyl)-1-piperazineethanesulfonic acidp-ChlorophenylalanineEDTAethylene glycol tetraacetic acidethylenediamine tetraacetic acidlong-term potentiationLTPspontaneous excitatory postsynaptic currentsPhosphate-buffered salinereverse transcription polymerase chain reaction
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Authors
A.W. Moreau, M. Amar, J. Callebert, P. Fossier,