| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6274945 | Neuroscience | 2013 | 10 Pages |
Abstract
⺠Heteromers form through electrostatic interactions of linear motifs located in disordered regions of receptors' proteins. ⺠Activation/inhibition of adenylate cyclase by Adenosine/Dopamine controls the production of cAMP which activates PKA. ⺠Phosphorylation of Ser/Thr by cAMP-activated PKA in the Arginine-rich epitope controls the stability of heteromers. ⺠Dopaminergic neurotransmission, through cAMP-dependent PKA slows down heteromerization. ⺠In heteromerization, phosphorylation is not just an on/off switch, by weakening noncovalent bonds, it acts like a rheostat.
Keywords
pKaLMSD4RD2RGPCRNCXA2ARNMDARD1RcAMPG-protein coupled receptorsCyclic adenosine monophosphateadenylate cyclaseNoncovalent interactionsPhosphorylationNoncovalent complexeslinear motifsdisordered proteinsprotein kinase Acasein kinaseDopamine D4 receptorDopamine D1 receptorN-methyl-d-aspartate receptorAdenosine receptorAdenosine A2A receptordopamine D2 receptorDopamine receptors
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Authors
A.S. Woods, S.N. Jackson,