| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6274946 | Neuroscience | 2013 | 16 Pages |
Abstract
⺠This study has demonstrated a key role of ERβ and GPR30 in the neuroprotective action of daidzein. ⺠Daidzein inhibited glutamate-induced apoptosis and neurotoxicity. ⺠Daidzein inhibited glutamate-stimulated protein expression of ERβ, without a significant change of GPR30. ⺠Involvement of ERβ and GPR30 in daidzein neuroprotection was verified with selective ligands and siRNAs. ⺠Biochemical data were supported by ERβ- and GPR30-specific immunofluorescence and confocal microscopy.
Keywords
EGTAG-protein-coupled receptor 30SERMGPR30Ac-DEVD-pNaDPNPHTPPHEPESPBSG15MPP4-(2-hydroxyethyl)-1-piperazineethanesulfonic acidDMSOethylene glycol tetraacetic acidICI 182,780ELISAEnzyme-linked immunosorbent assayApoptosisRoom temperatureDIVDimethyl sulfoxideNeurotoxicityPhytoestrogenlactate dehydrogenaseLDHPhosphate-buffered salineSelective estrogen receptor modulatorEstrogen receptorMembrane estrogen receptor
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Authors
M. Kajta, J. Rzemieniec, E. Litwa, W. Lason, M. Lenartowicz, W. Krzeptowski, A.K. Wojtowicz,