| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6274978 | Neuroscience | 2013 | 10 Pages |
Abstract
⺠We tested erythropoietin (EPO) neuroprotection after acute subdural hematoma in rats. ⺠We compared intravenous (i.v.) and direct cortical application after removal of subdural blood. ⺠200 and 2000 IU (i.v.) and 0.02 IU (direct cortical) EPO/rat were neuroprotective. ⺠20.000 (i.v.) and 2 IU (direct cortical) EPO/rat induced adverse effects on injury. ⺠Enhanced neuroprotection by blood evacuation and cortical EPO application.
Keywords
PI3-KPtiO2TBILDUAcute subdural hemorrhageEpoRrtPAHHTASDHICPEPOCBFTraumatic brain injuryerythropoietinRecombinant erythropoietinBrain tissue oxygencerebral blood flowBBBNeurotoxicityphosphatidylinositol-3-kinasemean arterial blood pressureintracranial pressureRecombinant tissue plasminogen activatorblood–brain-barrierRatmapErythropoietin Receptor
Related Topics
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Neuroscience
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Authors
M. Rahimi Nedjat, M. Wähmann, H. Bächli, E. Güresir, H. Vatter, A. Raabe, A. Heimann, O. Kempski, B. Alessandri,