| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6274980 | Neuroscience | 2013 | 10 Pages |
Abstract
⺠Creatine produced a protective effect against 6-hydroxydopamine-induced cell death. ⺠The protective effect of creatine involves PI3K/AKT, PKA and PKC. ⺠ERK1/2 and CaMKII modulation is implicated in the protective effect of creatine. ⺠Creatine reversed the decline in GSK-3β phosphorylation induced by 6-OHDA. ⺠Creatine could be a potent protective factor for catecholaminergic cell survival.
Keywords
mitogen-activated protein kinase kinase 1/2CaMKIIGSK-3β6-HydroxydopamineHEPESEMEMFBS6-OHDACREB4-(2-hydroxyethyl)-1-piperazineethanesulfonic acidBDNFCa2+/calmodulin-dependent protein kinase IIDMSOERK1/2MEK1/2MPP+Adenosine TriphosphateATPanalysis of varianceANOVAEagle’s Minimum Essential MediumDimethyl sulfoxidefetal bovine serumBrain-derived neurotrophic factorlactate dehydrogenaseLDHcyclic adenosine monophosphate response element-binding proteinCreatine kinaseextracellular signal-regulated kinasesGlycogen synthase kinase-3β
Related Topics
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Neuroscience (General)
Authors
M.P. Cunha, M.D. MartÃn-de-Saavedra, A. Romero, E. Parada, J. Egea, L. del Barrio, A.L.S. Rodrigues, M.G. López,