Neural transdifferentiation of human bone marrow mesenchymal stem cells on hydrophobic polymer-modified surface and therapeutic effects in an animal model of ischemic stroke

Article ID	Journal	Published Year	Pages	File Type
6275000	Neuroscience	2013	14 Pages	PDF

Abstract

âº Human bone marrow-derived mesenchymal stem cells were differentiated to neural lineage cells. âº MSCs differentiated to neurosphere-like aggregates (NS-MSC) efficiently on DTOPV-coated surface. âº NS-MSCs via paracrine action contributed to functional recovery and reduction in infarct area. âº NS-MSCs could be a promising stem source for cell therapy in neurodegeneration.

Keywords

Dcx ethylenediamminetetraacetate 7-aminoactinomycin D 7-AAD COMP CFSE pMCAO mNSS PSA-NCAM PFA DAPI MSC PBS NSC FBS 4′6-diamidino-2-phenylindole BSA hESC P/S bovine serum albumin EDTA Permanent middle cerebral artery occlusion Differentiation doublecortin fetal bovine serum Human embryonic stem cell Mesenchymal stem cells Neural stem cells Phosphate-buffered saline bone marrow modified neurological severity score Neurosphere paraformaldehyde Cartilage oligomeric matrix protein Penicillin/streptomycin carboxyfluorescein succinimidyl ester