Brain-derived neurotrophic factor, acting at the spinal cord level, participates in bladder hyperactivity and referred pain during chronic bladder inflammation

Article ID	Journal	Published Year	Pages	File Type
6275004	Neuroscience	2013	15 Pages	PDF

Abstract

âº Single intrathecal BDNF injection caused transient bladder hyperactivity and pain. âº Chronic intrathecal administration of BDNF induced cutaneous hypersensitivity. âº Chronic intrathecal administration of BDNF did not affect bladder reflex activity. âº Intrathecal BDNF blockade reduced pain and bladder hyperactivity during cystitis.

Keywords

PBST ILG Mechanical thresholds PBS containing 0.3% Triton X-100 NTS MTS ERK DCM CyP ABC DAB PBS AUC BDNF inflammation standard deviation immunoreactive ANOVA Visceral pain Cystitis Cyclophosphamide Brain-derived neurotrophic factor Bladder area under the curve Neurotrophins avidin–biotin complex extracellular signal-regulated kinase