Neonatal lipopolysaccharide exposure induces long-lasting learning impairment, less anxiety-like response and hippocampal injury in adult rats

Article ID	Journal	Published Year	Pages	File Type
6275011	Neuroscience	2013	12 Pages	PDF

Abstract

âº Neonatal LPS exposure results in long-lasting learning deficits in adult rats. âº Neonatal LPS exposure causes long-lasting anxiolytic responses in adult rats. âº Neonatal LPS exposure causes persistent hippocampal injuries in adult rats. âº Neonatal LPS exposure results in chronic inflammatory responses in adult rats.

Keywords

TNFα Anxiolytic behavior map1 NIH NeuN IL-1β DAPI IL-6 LPS Chronic inflammation interleukin-6 Interleukin-1β Enzyme-linked immunosorbent assay ELISA substantia nigra tumor necrosis factor-α intracerebral postnatal day 5 lipopolysaccharide National Institutes of Health i.c.Hippocampus neuron-specific nuclear protein