Article ID Journal Published Year Pages File Type
6275024 Neuroscience 2013 9 Pages PDF
Abstract
► Cerebellar muscarinic M1/2/3 receptor was decreased due to neonatal hypoxia. ► Acetylcholine metabolism was also disturbed - leading to metabolic shift. ► Glucose resuscitation, alone and with oxygen, reversed the cholinergic alterations. ► Common clinical practice of 100% oxygen or epinephrine upset the cholinergic system. ► This highlights the importance of glucose supplementation in neonatal care to hypoxia.
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