The role of the serotonergic system at the interface of aggression and suicide

Article ID	Journal	Published Year	Pages	File Type
6275028	Neuroscience	2013	26 Pages	PDF

Abstract

âº Implications of 5-HT-ergic dysfunctions in aggression and suicide. âº Review of the anatomical distribution of the 5-HT-ergic system in the brain. âº Review of 5-HT receptors, transporter, synthesis and metabolic enzymes. âº Interaction of genetic, environmental and gender on aggression and suicide.

Keywords

5-HTT OFC SSRIs 5-HIAA MAO DRN AP2 PAG Activator protein-2 MPFC N-methyl-d-aspartate 5-HTTLPR NMDA IPSP MRN IBTS l-aromatic amino acid decarboxylase NRP DGGE nucleus raphe obscurus Buss-Durkee Hostility Inventory SNPs BDHI AADC NAC NRO NRM EPSPs NPY 5-Hydroxyindoleacetic acid ddC dopa decarboxylase immunoreactive FAD Positron emission tomography 5-HT transporter periaqueductal gray HIS insertion/deletion Gastrointestinal DGGE, denaturing gradient gel electrophoresis orbitofrontal cortex medial prefrontal cortex monoamine oxidase knockout Nucleus accumbens nucleus raphe magnus nucleus raphe pallidus median raphe nucleus dorsal raphe nucleus Aromatic amino acid hydroxylase Parvalbumin PET inhibitory post-synaptic potentials excitatory post-synaptic potentials Single nucleotide polymorphisms calbindin Neuropeptide Y