| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6275054 | Neuroscience | 2013 | 15 Pages |
Abstract
⺠Intranasal (IN) infusion can deliver NPY to brain without changing plasma levels. ⺠IN NPY reduced PTSD-like behavior induced by single prolonged stress (SPS). ⺠IN NPY attenuated SPS-induced activation of HPA axis and TH mRNA in locus coeruleus. ⺠IN NPY prevented single prolonged stress-triggered rise of GR in the hippocampus. ⺠IN NPY has potential as treatment against harmful effects of traumatic stress.
Keywords
ICVACTHMPFCintracerebroventricularASRFSTNPYEPMCRHDBHforced swim testEDTAEthylenediaminetetraacetic acidIntranasalelevated plus mazedopamine beta-hydroxylaseforced swimmedial prefrontal cortexlocus coeruleusHPAnorepinephrineadrenocorticotropic hormonecorticotropin-releasing hormonehypothalamic–pituitary–adrenalacoustic startle responseMineralocorticoid receptorsglucocorticoid receptorNeuropeptide Y
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Authors
L.I. Serova, A. Tillinger, L.G. Alaluf, M. Laukova, K. Keegan, E.L. Sabban,