| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6275072 | Neuroscience | 2013 | 13 Pages |
Abstract
⺠Quercetin is a potential mitochondrial stimulant and up-regulates complex-I activity. ⺠Quercetin protects against rotenone-induced PCD of dopaminergic neurons. ⺠Quercetin acts as a potent hydroxyl radical scavenger in mitochondria. ⺠Quercetin reverses rotenone-induced glutathione loss in the nigra. ⺠Quercetin attenuates amphetamine-induced rotations in experimental PD.
Keywords
6-OHDAPCDDHBABN-PAGENADPH-dMPTPGSH6-HydroxydopamineGSSG1-methyl-4-phenyl-1,2,3,6-tetrahydropyridineMPP+ROSSNpc·OHEDTAethylenediamine tetraacetic acidblue native-polyacrylamide gel electrophoresisParkinson’s diseasesubstantia nigra pars compactaTUNELtyrosine hydroxylaseDopaminedihydroxybenzoic acidHydroxyl radicalelectron transport chainSODSuperoxide dismutaseProgrammed cell deathNADHETcreduced nicotinamide adenine dinucleotidereduced glutathioneoxidized glutathioneReactive oxygen species
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Authors
S.S. Karuppagounder, S.K. Madathil, M. Pandey, R. Haobam, U. Rajamma, K.P. Mohanakumar,