Attenuation of MPTP/MPP+ toxicity in vivo and in vitro by an 18-mer peptide derived from prosaposin

Article ID	Journal	Published Year	Pages	File Type
6275082	Neuroscience	2013	21 Pages	PDF

Abstract

âº PS18 protects dopaminergic neuron from MPTP-induced neurotoxicity. âº PS18 attenuates MPP+-induced SH-SY5Y cell death. âº PS18 inhibits apoptosis-related protein in MPTP/MPP+-induced cell death. âº PS18 inhibits astrocyte activation in MPTP-induced Parkinson's disease.

Keywords

DAPI 1-methyl-4-phenylpyridinium ion Dulbecco’s Minimum Essential Medium SH-SY5Y MPTP DAT ALT FBS DMEM PBS Jnk 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 4′-6-diamidino-2-phenylindole BSA c-Jun N-terminal kinase H&E MPP+SNpc AST alanine transaminase bovine serum albumin EDTA Ethylenediaminetetraacetic acid Dopamine transporter standard deviation Parkinson’s disease aspartate transaminase substantia nigra tyrosine hydroxylase standard error of the mean BUN Dopamine fetal bovine serum Phosphate-buffered saline SEM norepinephrine Dopaminergic neurons blood urea nitrogen Hematoxylin and Eosin anti-glial fibrillary acidic protein creatinine