| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6275094 | Neuroscience | 2013 | 11 Pages |
Abstract
⺠hASCs were differentiated to Schwann cell-like cells with a mixture of growth factors. ⺠Differentiated hASCs secreted neurotrophic factors and promoted neurite outgrowth. ⺠hASCs transplanted into nude rats survived and formed myelin on regenerating axons. ⺠In vitro differentiation improved survival and myelin-forming rates of hASCs in vivo.
Keywords
ASCsTissue Protein Extraction ReagentT-PERhuman Schwann cellsb-FGFHSCsGDNFNGFPFAHBSSGFPPBSMBPGFAPFBSMSCsBDNFBSAhASCsbovine serum albuminGlial differentiationfetal bovine serumSchwann cellAdipose-derived stem cellsHuman adipose-derived stem cellhuman adipose-derived stem cellsMesenchymal stem cellsNeurotrophic factorPeripheral nervenerve growth factorbasic fibroblast growth factorBrain-derived neurotrophic factorglial cell-derived neurotrophic factorphycoerythrinPhosphate-buffered salineHank’s balanced salt solutionMyelinationparaformaldehydeGlial fibrillary acidic proteingreen fluorescent proteinMyelin basic protein
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Authors
K. Tomita, T. Madura, Y. Sakai, K. Yano, G. Terenghi, K. Hosokawa,