Poly(ADP-ribose) polymerase inhibition protects epileptic hippocampal neurons from apoptosis via suppressing Akt-mediated apoptosis-inducing factor translocation in vitro

Article ID	Journal	Published Year	Pages	File Type
6275109	Neuroscience	2013	10 Pages	PDF

Abstract

âº PARP is activated in the HNC model of AE. âº Inhibition of PARP activity protects epileptic hippocampal neurons from caspase-independent apoptosis in the HNC model of AE. âº Inhibition of PARP activity promotes the phosphorylation of Akt and GSK3Î². âº Inhibition of PARP activity suppresses mitochondria-nucleus translation of AIF mediated by PI-3K/Akt pathway.

Keywords

PARP Apoptosis-inducing factor (AIF)PBRs HNC dpq WCC PARP inhibition SRED 3,4-dihydro-5-[4-(1-piperidinyl)butoxy]-1(2H)-isoquinolinone HEPES CLSM 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid NAD+AIF Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling seizure Par TUNEL acquired epilepsy apoptosis-inducing factor lactate dehydrogenase LDH confocal laser scanning microscopy nicotinamide adenine dinucleotide wortmannin Poly(ADP-ribose)Poly(ADP-ribose) polymerase