Loss of survivin in neural precursor cells results in impaired long-term potentiation in the dentate gyrus and CA1-region

Article ID	Journal	Published Year	Pages	File Type
6275113	Neuroscience	2013	7 Pages	PDF

Abstract

âº Prenatal deletion of survivin results in deteriorated hippocampal synaptic plasticity. âº SurvivinCamcre mice show impaired long-term potentiation in the dentate gyrus and the Cornu Ammonis area 1-region. âº Basal hippocampal excitability and synaptic transmission are normal. âº Short-term synaptic plasticity is unchanged. âº In addition to neurogenesis, survivin has a specific role in synaptic plasticity.

Keywords

nuclear factor ‘kappa-light-chain-enhancer’ of activated B-cells aCSF AMPA IAP SGZ HSP90 TBS RM-ANOVA SVZ CA1 CRE αCaMKII Survivin fEPSPs I/O NPCs α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor cornu ammonis area 1 ISI Electroencephalography repeated measures analysis of variance Theta-burst stimulation analysis of variance ANOVA long-term potentiation LTP standard errors of the mean Room temperature Neural precursor cells dentate gyrus cAMP response element inter-stimulus interval artificial cerebrospinal fluid SEM subgranular zone subventricular zone EEG Neurogenesis Polimerase Chain Reaction PCR input/output excitatory post-synaptic potentials Heat shock protein 90 inhibitor-of-apoptosis protein Picrotoxin