Exacerbated inflammatory responses related to activated microglia after traumatic brain injury in progranulin-deficient mice

Article ID	Journal	Published Year	Pages	File Type
6275134	Neuroscience	2013	12 Pages	PDF

Abstract

âº The role of progranulin (PGRN) in neuroinflammatory responses was studied. âº PGRN expression in CD68-positive microglia increased on traumatic brain injury (TBI). âº PGRN-deficient mice had a higher expression of CD68 and TGFÎ²1 in the brain after TBI. âº PGRN deficiency resulted in enhanced protein oxidation and laminin immunoreactivity. âº PGRN may suppress excessive inflammatory responses related to activated microglia after TBI.

Keywords

NeuN TNF TBI PGRN pNPP TNFR Hprt NCL TDP-43 FTLD IBA1 TBST PMSF TGFβ PBST TBS PBS PVDF GFAP neuronal ceroid lipofuscinosis p-nitrophenyl phosphate Traumatic brain injury Spinal cord injury neuronal nuclear antigen EDTA Ethylenediaminetetraacetic acid amyotrophic lateral sclerosis Neuroinflammation immunoreactive Alzheimer’s disease ALS transforming growth factor Tris-buffered saline frontotemporal lobar degeneration sci tumor necrosis factor phenylmethylsulfonyl fluoride Phosphate-buffered saline ionized calcium-binding adaptor molecule 1 Microglia wild-type Nitric oxide Hematoxylin and Eosin hypoxanthine phosphoribosyltransferase Glial fibrillary acidic protein Progranulin Polyvinylidene fluoride Protein carbonyl groups Tumor necrosis factor receptors