| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6275155 | Neuroscience | 2013 | 10 Pages |
Abstract
⺠High K+ depolarization protects dopaminergic neurons from MPP+ cytotoxicity. ⺠The protective effect is dependent on nitric oxide and protein kinase G (PKG). ⺠8-Nitro-cGMP is produced in response to high K+ depolarization. ⺠8-Nitro-cGMP confers neuroprotection in a PKG-dependent manner. ⺠PKG-independent expression of heme oxygenase-1 is also involved in neuroprotection.
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Authors
Y. Kurauchi, A. Hisatsune, Y. Isohama, T. Sawa, T. Akaike, H. Katsuki,