| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6275170 | Neuroscience | 2013 | 13 Pages |
Abstract
⺠Linearol and sidol are kaurane diterpenes with antioxidant properties. ⺠They prevent H2O2-induced oxidative stress in U373-MG. ⺠They decreased ROS levels and reduced lipid peroxidation. ⺠They restored enzymatic and nonenzymatic antioxidant defense system. ⺠Nrf2 a nuclear, antioxidant gene expression regulator, was involved in this protection.
Keywords
NADPHnuclear factor-erythroid 2Kaurane diterpenesMDAHemeoxygenase-1tert-butylhydroperoxideGSSGHO-1GPXGSHNrf2CATORACDMEMFBS3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromideAUCDMSOMTTROSt-BHPAstrocytesAntioxidantEDTAEthylenediaminetetraacetic acidOxidative stressDimethylsulfoxideSODfetal bovine serumSuperoxide dismutaseoxygen radical absorbance capacitylactate dehydrogenaseLDHmalondialdehydeNeuroprotectionDulbecco’s modified eagle’s mediumNrf2 pathwayarea under curvenicotinamide adenine dinucleotide phosphateCatalasereduced glutathionehigh-performance liquid chromatographyHPLCoxidized glutathioneglutathione reductaseglutathione peroxidaseReactive oxygen species
Related Topics
Life Sciences
Neuroscience
Neuroscience (General)
Authors
E. González-Burgos, M.E. Carretero, M.P. Gómez-Serranillos,