| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6275182 | Neuroscience | 2013 | 13 Pages |
Abstract
⺠Ang (5-8) injection into PAG selectively elicits Ang-R-mediated antinociception. ⺠The PAG both synthesizes and inactivates Ang (5-8). ⺠Ang (5-8) modulates antinociception via NO-sGC pathway and opioid. ⺠Ang (5-8) antinociception is 74-fold more potent than that of morphine. ⺠Ang (5-8) can be a leading compound to develop potent and selective analgesic drugs.
Keywords
nNOSNω-propyl-l-arginineODQNPLASGCvlPAGRASATRPBSDMSOAngiotensinsanalysis of varianceANOVAtail-flick testSoluble guanylyl cyclasePainDimethylsulfoxideneuronal nitric oxide synthaseRenin–angiotensin systemAntinociceptionHeart ratemean arterial pressureAntinociceptive activityPeriaqueductal gray matterPhosphate-buffered salinemapNitric oxideOpioid receptor
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Neuroscience
Neuroscience (General)
Authors
L.M. Guethe, A. Pelegrini-da-Silva, K.G. Borelli, M.A. Juliano, G.G. Pelosi, J.B. Pesquero, C.L.M. Silva, F.M.A. Corrêa, F. Murad, W.A. Prado, A.R. Martins,